Cat. No.: HY-N0615

Notoginsenoside R1

(Synonyms: Sanchinoside R1; Sanqi glucoside R1)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 80418-24-2
Formula: C₄₇H₈₀O₁₈
Molecular Weight:933.13

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Notoginsenoside R1 Chemical Structure

CAS No.: 80418-24-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Notoginsenoside R1 (2.5-80 μM; 24 h) inhibits the hypoxia-reoxygenation (H/R)-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes^[1].
? Notoginsenoside R1 (5-20 μM; 24 h) inhibits the H/R-induced H9c2 cardiomyocytes apoptosis in a concentration-dependent manner^[1].
? Notoginsenoside R1 (1-100 μM; 24 h) dose-dependently protects PC12 cells and primary neurons from Aβ-induced cell death and apoptosis^[2].
? Notoginsenoside R1 (10 μM; 24 h) inhibits Aβ_25-35-induced ROS production, mitochondrial damage and MAPK activation in PC12 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley (SD) rats (200-250 g)^[3]
Dosage:

5 mg/kg/h
Administration:

Infused 20 min before LPS infusion via the right jugular vein
Result:

Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.
Attenuated the LPS-induced adhesion of leukocytes to the venular wall.
Inhibited mast cell degranulation and cytokine elevation.

Chemical Information

CAS No. 80418-24-2
Appearance Solid
Molecular Weight 933.13
Formula C₄₇H₈₀O₁₈
Color White to off-white
SMILES

C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@@](OC[C@@H](O)[C@@H]5O)([H])[C@@H]5O)[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)([H])CC6)C
Synonyms

Sanchinoside R1; Sanqi glucoside R1
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

All IFWBCell Proliferation/Viability AssayBio/Physico-chemical AssayIn Vivo Efficacy Study

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Journal Impact Factor

Mater Des

2026 Apr 19;266:116048.
Front Cell Neurosci

Notoginsenoside R1-Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav. [Abstract]

2020 Sep 4;14:280. PMID: 33088260

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280. [Abstract]

Effect of Notoginsenoside R1 (R1; 5 μM) on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280. [Abstract]

Effect of Notoginsenoside R1 (R1, 5 μM) on Aβ1-42 (5 μM)–induced neuron viability determined using MTT assay. Cell viability of cultured neurons treated with different groups at 0 h, 24 h, 48 h, 72 h, and 96 h.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280. [Abstract]

Notoginsenoside R1 (R1, 5 μM) was responsible for reducing abnormal excitability in Aβ1-42–induced neurons.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280. [Abstract]

Notoginsenoside R1 (R1, 5 mg/kg; i.g.; once daily for 6 months) partially improved the Marris Water Maze (MWM) test behavior in APP/PS1 mice.
Animals (Basel)

Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro by Restoring SERCA2-Mediated Calcium Homeostasis. [Abstract]

2026 Jun 14;16(12):1836. PMID: 42353446
Res Sq

2024 Jul 12.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

Notoginsenoside R1 (NGR1, 2.5-20 μM; 24 h) treatment did not significantly affect the cell viability of PPARγ/PPRE-transfected HT22 cells.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

Notoginsenoside R1 (NGR1, 2.5-20 μM; 24 h) treatment notably increased the luciferase activity in the PPARγ/PPRE-transfected HT22 cells.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

Notoginsenoside R1 (NGR1, 10 µM; 24 h) treatment promoted GLUT4 membrane translocation in primary mouse hippocampal neurons. Scale bar = 20 μm.

Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

Notoginsenoside R1 (NGR1, 10-80 mg/kg; i.g.; 16 weeks) treatment dramatically decreased the levels of fasting blood glucose in APP/PS1xdb/db mice in a dose-dependent manner.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (107.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0717 mL

5.3583 mL

10.7166 mL

5 mM

0.2143 mL

1.0717 mL

2.1433 mL

10 mM

0.1072 mL

0.5358 mL

1.0717 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu Y, et, al. Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways. Sci Rep. 2016 Feb 18;6:21730. [Content Brief]

[2]. Ma B, et, al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Sep;22(1):151-9. [Content Brief]

[3]. Sun K, et, al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci. 2007 Jul 19;81(6):509-18. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0717 mL	5.3583 mL	10.7166 mL	26.7916 mL
	5 mM	0.2143 mL	1.0717 mL	2.1433 mL	5.3583 mL
	10 mM	0.1072 mL	0.5358 mL	1.0717 mL	2.6792 mL
	15 mM	0.0714 mL	0.3572 mL	0.7144 mL	1.7861 mL
	20 mM	0.0536 mL	0.2679 mL	0.5358 mL	1.3396 mL
	25 mM	0.0429 mL	0.2143 mL	0.4287 mL	1.0717 mL
	30 mM	0.0357 mL	0.1786 mL	0.3572 mL	0.8931 mL
	40 mM	0.0268 mL	0.1340 mL	0.2679 mL	0.6698 mL
	50 mM	0.0214 mL	0.1072 mL	0.2143 mL	0.5358 mL
	60 mM	0.0179 mL	0.0893 mL	0.1786 mL	0.4465 mL
	80 mM	0.0134 mL	0.0670 mL	0.1340 mL	0.3349 mL
	100 mM	0.0107 mL	0.0536 mL	0.1072 mL	0.2679 mL

Notoginsenoside R1

4 Cited Publications

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Notoginsenoside R1

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Publications Citing Use of MedChemExpress (MCE) Notoginsenoside R1

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Notoginsenoside R1 Related Classifications

HY-N0615 Related Classifications