2. Anti-infection
  3. RSV
  4. NIAID RSVF2-5

NIAID RSVF2-5 is a human monoclonal antibody fragment. NIAID RSVF2-5 binds to conserved, distinct conformational epitopes on RSV fusion glycoprotein, and shows activity against RSV subgroup A and B strains. NIAID RSVF2-5 reduces pulmonary and lung viral titers in RSV-infected rodents. NIAID RSVF2-5 can be used for the research of respiratory syncytial virus infection.

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NIAID RSVF2-5

NIAID RSVF2-5 Chemical Structure

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NIAID RSVF2-5 Related Antibodies

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Description

NIAID RSVF2-5 is a human monoclonal antibody fragment. NIAID RSVF2-5 binds to conserved, distinct conformational epitopes on RSV fusion glycoprotein, and shows activity against RSV subgroup A and B strains. NIAID RSVF2-5 reduces pulmonary and lung viral titers in RSV-infected rodents. NIAID RSVF2-5 can be used for the research of respiratory syncytial virus infection[1][2].

Species Reactivity

Human
In Vitro

NIAID RSVF2-5 neutralizes RSV Tracy (subgroup A) and RSV 18537 (subgroup B) in HEp-2 cells with IC50 values of 3.6 μg/mL and 1.8 μg/mL, respectively[2].
NIAID RSVF2-5 neutralizes RSV A2 (subgroup A) in HEp-2 cells with an IC60 of 0.07 μg/mL[2].
NIAID RSVF2-5 binds to purified RSV A2 strain gF protein with a KD of 4.9 × 10-10 M[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NIAID RSVF2-5 Related Antibodies
In Vivo

NIAID RSVF2-5 (0.0039-4.0 mg/kg; i.n.; single dose; day 4 after infection) reduces pulmonary RSV titer in RSV-infected BALB/c mice[1].
NIAID RSVF2-5 (5-15 mg/kg; i.p. or i.m.; single dose; 1 day prior to challenge) significantly reduces lung viral titers in RSV-challenged cotton rats when administered prophylactically[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (female, 42 weeks old, average weight 25 g) intranasally inoculated with RSV strain A2[1]
Dosage: 0.0039; 0.0156; 0.0625; 0.25; 1.0; 4.0 mg/kg
Administration: i.n.; single dose; on day 4 after infection
Result: Achieved a 2000-fold reduction in mean lung RSV titer (to 1.9 log10 pfu/g) with virus detected in only 1 of 6 animals at 4.0 mg/kg; reduced mean nasal turbinate RSV titer to 3.2 log10 pfu/g at 4.0 mg/kg.
Reduced mean lung RSV titer to 3.3 log10 pfu/g and mean nasal turbinate RSV titer to 3.8 log10 pfu/g at 1.0 mg/kg.
Reduced mean lung RSV titer to 4.3 log10 pfu/g and mean nasal turbinate RSV titer to 4.4 log10 pfu/g at 0.25 mg/kg.
Reduced mean lung RSV titer to 4.0 log10 pfu/g and mean nasal turbinate RSV titer to 4.2 log10 pfu/g at 0.0625 mg/kg.
Showed no significant reduction in lung or nasal turbinate RSV titers relative to untreated controls at 0.0156 mg/kg and 0.0039 mg/kg.
Animal Model: Sigmodon hispidis (60-125 g) intranasally administered with RSV[2]
Dosage: 15; 5 mg/kg (i.p.); 12 mg/kg (i.m.)
Administration: i.p. or i.m.; single dose 1 day prior to challenge
Result: Showed no significant reduction in nasal titer at 15 mg/kg (i.p.), with nasal titer measured at 4.95 log10 total PFU.
Reduced lung titer by 0.93 log10 (9-fold) from control at 15 mg/kg (i.p.), with lung titer at 3.96 log10 PFU/g.
Showed no significant reduction in nasal titer at 5 mg/kg (i.p.), with nasal titer measured at 4.90 log10 total PFU.
Reduced lung titer by 0.59 log10 from control at 5 mg/kg (i.p.), with lung titer at 4.3 log10 PFU/g.
Showed no significant reduction in nasal titer at 12 mg/kg (i.m.), with nasal titer measured at 4.45 log10 total PFU.
Reduced lung titer by 1.21 log10 (17-fold) from control at 12 mg/kg (i.m.), with lung titer at 3.7 log10 PFU/g.
Accession

A0A0X8XRK2
Target

RSV-F
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NIAID RSVF2-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NIAID RSVF2-5RSVRespiratory syncytial virusBALB/c miceRSV fusion glycoproteinRSV subgroup Acotton ratsRSV subgroup BHIV-1 gp120hepatitis B virus surface proteinRSV G glycoproteinHEp-2 cellsrespiratory syncytial virusInhibitorinhibitorinhibit

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