815619-12-6
815619-12-6
Chemical Structure
NTU281
- CAS No.: 815619-12-6
- Formula:C25H31N2O6S+
- Molecular Weight:487.59
IUPAC Name: (5S,8S)-5-benzyl-8-carboxy-13-methyl-3,6,11-trioxo-1-phenyl-2-oxa-13-thia-4,7-diazatetradecan-13-ium
InChIKey: MQKDBWQFOOQINN-VXKWHMMOSA-O
SMILES: O=C(N[C@H](C(N[C@@H](CCC(C[S+](C)C)=O)C(O)=O)=O)CC1=CC=CC=C1)OCC2=CC=CC=C2
Biological Activity: NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes[1][2].
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NTU281 | NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes. | |||||||||||||||||||||
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References
- [1]. Hornigold N, et al. Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy. Lab Invest. 2013 May;93(5):553-65. [Content Brief]
- [2]. Huang L, et al. Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy? Nephrol Dial Transplant. 2010 Dec;25(12):3897-910. [Content Brief]
