country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DGKQ - diacylglycerol kinase theta Gene

Also Known as DAGK; DAGK4; DAGK7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1609

About DGKQ

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:958,887-973,569 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 9 paralogues. Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues.

Summary

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

DGKQ Products (1)

mRNA	Protein	Name
NM_001347.4	NP_001338.2	diacylglycerol kinase theta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	9099683	GOA
enables ATP-dependent diacylglycerol kinase activity	IMP IMP: Inferred from mutant phenotype	23091060	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17664281	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	15632189	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	12799190	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10066731	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	22732145	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	17664281	GOA
involved in cellular response to bile acid	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	9099683	GOA
involved in glycerolipid metabolic process	IDA IDA: Inferred from direct assay	22627129	GOA
involved in lipid phosphorylation	IDA IDA: Inferred from direct assay	9099683	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	22732145	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IGI IGI: Inferred from genetic interaction	22732145	GOA
involved in phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	9099683	GOA
involved in phosphatidic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	23610160	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15632189	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22732145	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22732145	GOA
involved in regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of cortisol biosynthetic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in regulation of progesterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17664281	GOA
involved in response to cAMP	IDA IDA: Inferred from direct assay	23610160	GOA
involved in thrombin-activated receptor signaling pathway	IDA IDA: Inferred from direct assay	15632189	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	10066731	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10066731	GOA
located in endosome	IDA IDA: Inferred from direct assay	22732145	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	12799190	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15632189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10066731	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	23091060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKQ Protein Structure

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
800
942 a.a.

Protein Preferred Names	Protein Names
diacylglycerol kinase theta	DAG kinase theta

DGKQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinal Degeneration	Degeneration Of Retina
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03723	DGKQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DGKQ	VGNC	VGNC:28031
Mus musculus	DGKQ	MGD	MGI:102918
Felis catus	DGKQ	VGNC	VGNC:61463
Rattus norvegicus	DGKQ	RGD	RGD:2320722
Macaca mulatta	DGKQ	VGNC	VGNC:71788
Canis familiaris	DGKQ	VGNC	VGNC:39923
Others	DGKQ	NCBI