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Cat. No.: HY-158322

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nsp12-IN-1

Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus.

For research use only. We do not sell to patients.

Formula: C₁₃H₁₆FN₅O₅
Molecular Weight:341.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

nsp12-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus^[1].

In Vitro

Nsp12-IN-1 has a high selectivity index and is less toxic to cells at effective antiviral concentrations, showing antiviral activity against SARS-CoV-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Nsp12-IN-1 (2 mg/kg, i.v.; 30mg/kg p.o.; 24h) improves oral bioavailability, but the absolute bioavailability of these compounds remains low in female Balb-c mice^[1].

Pharmacokinetic Analysis in female Balb-c mice^[1]

Dosed compound	Route	Dose (mg/kg)	AUClast (ng•h/mL)	T_1/2 (h)	T_max (h)	C_max (ng/mL)	F (%)
10n	i.v.	2	118	1.2	0.50	55	/
10n	p.o.	30	171	4.3	2.0	49	9.6
12a	p.o.	30	504	1.5	1.0	190	28.4
12b	p.o.	30	847	3.4	0.67	301	47.7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 341.30
Formula C₁₃H₁₆FN₅O₅
SMILES

O[C@H]1[C@@H](O)[C@H](C2=CC(C(N)=O)=C3C(N)=NC(CF)=NN32)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mesaros E F, Dugan B J, Gao M, et al. Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2[J]. ACS Infectious Diseases, 2024. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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