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United States

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Cat. No.: HY-158322

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nsp12-IN-1

Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus.

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Formule: C₁₃H₁₆FN₅O₅
Masse moléculaire:341.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

nsp12-IN-1 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus^[1].

In Vitro

Nsp12-IN-1 has a high selectivity index and is less toxic to cells at effective antiviral concentrations, showing antiviral activity against SARS-CoV-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nsp12-IN-1 (2 mg/kg, i.v.; 30mg/kg p.o.; 24h) improves oral bioavailability, but the absolute bioavailability of these compounds remains low in female Balb-c mice^[1].

Pharmacokinetic Analysis in female Balb-c mice^[1]

Dosed compound	Route	Dose (mg/kg)	AUClast (ng•h/mL)	T_1/2 (h)	T_max (h)	C_max (ng/mL)	F (%)
10n	i.v.	2	118	1.2	0.50	55	/
10n	p.o.	30	171	4.3	2.0	49	9.6
12a	p.o.	30	504	1.5	1.0	190	28.4
12b	p.o.	30	847	3.4	0.67	301	47.7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 341.30
Formule C₁₃H₁₆FN₅O₅
SMILES

O[C@H]1[C@@H](O)[C@H](C2=CC(C(N)=O)=C3C(N)=NC(CF)=NN32)O[C@@H]1CO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mesaros E F, Dugan B J, Gao M, et al. Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2[J]. ACS Infectious Diseases, 2024. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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