2. Metabolic Enzyme/Protease Apoptosis
  3. MMP Apoptosis
  4. Nudol

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.

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Nudol

Nudol 構造式

CAS 番号 : 86630-46-8

容量 価格（税別） 在庫状況 数量
1 mg $164 在庫あり
5 mg $410 在庫あり
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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Nudol 関連抗体

Top Publications Citing Use of Products

MMP アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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製品説明

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2].

IC50 & Target[2]

MMP-2

988.9 nM (Ki)

MMP-9

1.76 μM (Ki)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 15
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
HSC-T6 IC50
> 100 μM
Compound: 13
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
[PMID: 18052323]
HeLa IC50
> 10 μM
Compound: 15
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
MCF7 IC50
> 10 μM
Compound: 15
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
Neutrophil IC50
1.7 μM
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochalasin B-induction by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochalasin B-induction by spectrophotometric analysis
[PMID: 27525452]
Neutrophil IC50
> 10 μM
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
[PMID: 27525452]
体外実験

Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines[1].
Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells[1].
Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells[1].
Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nudol 関連抗体

Cell Viability Assay[1]

Cell Line: U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells
Concentration: 0, 10, 20, 30, 40 μM
Incubation Time: 24, 48, and 72 h
Result: Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners.

Cell Cycle Analysis[1]

Cell Line: U2OS cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24, 48, and 72 h
Result: Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10).

Western Blot Analysis[1]

Cell Line: U2OS cells
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 24, 48, and 72 h
Result: Increased the protein level of cytochrome c.
Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax.
分子量

270.28

分子式

C16H14O4
CAS 番号
Appearance

Solid

Color

Off-white to light brown

SMILES

OC1=C(OC)C(OC)=C2C3=CC=C(O)C=C3C=CC2=C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
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Nudol Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nudol86630-46-8MMPApoptosisMatrix metalloproteinasesAnti-proliferationphenanthreneanti-tumoranti-cancerosteosarcomaU2OSapoptosisInhibitorinhibitorinhibit

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製品名:
Nudol
製品番号:
HY-N7385
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