2. GPCR/G Protein
  3. LPL Receptor
  4. ONO-0740556

ONO-0740556 is a potent Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with an EC50 value of 0.26 nM.

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ONO-0740556

ONO-0740556 構造式

CAS 番号 : 2250210-69-4

容量 価格（税別） 在庫状況 数量
5 mg $780 在庫あり
10 mg $1250 在庫あり
25 mg $2500 在庫あり
50 mg $4050 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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ONO-0740556 関連抗体

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LPL Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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製品説明

ONO-0740556 is a potent Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with an EC50 value of 0.26 nM[1].

体外実験

ONO-0740556 engages in extensive interactions with the N-terminus, extracellular loops 1 and 2 (ECL1, ECL2), and transmembrane domains 2, 3, 5, 6, and 7 (TM2, TM3, TM5, TM6, TM7) of the receptor. Its binding site consists of two parts: a polar recognition region on the extracellular side and a hydrophobic pocket within the transmembrane region. This binding mode is also observed in S1P receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ONO-0740556 関連抗体
分子量

415.46

分子式

C20H34NO6P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OC[C@@H](CO)NC(CCCCC1=C(C=CC=C1)CCCCCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 75 mg/mL (180.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4070 mL 12.0349 mL 24.0697 mL
5 mM 0.4814 mL 2.4070 mL 4.8139 mL
10 mM 0.2407 mL 1.2035 mL 2.4070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4070 mL 12.0349 mL 24.0697 mL 60.1743 mL
5 mM 0.4814 mL 2.4070 mL 4.8139 mL 12.0349 mL
10 mM 0.2407 mL 1.2035 mL 2.4070 mL 6.0174 mL
15 mM 0.1605 mL 0.8023 mL 1.6046 mL 4.0116 mL
20 mM 0.1203 mL 0.6017 mL 1.2035 mL 3.0087 mL
25 mM 0.0963 mL 0.4814 mL 0.9628 mL 2.4070 mL
30 mM 0.0802 mL 0.4012 mL 0.8023 mL 2.0058 mL
40 mM 0.0602 mL 0.3009 mL 0.6017 mL 1.5044 mL
50 mM 0.0481 mL 0.2407 mL 0.4814 mL 1.2035 mL
60 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0029 mL
80 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.7522 mL
100 mM 0.0241 mL 0.1203 mL 0.2407 mL 0.6017 mL
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ONO-0740556 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-07405562250210-69-4ONO0740556ONO 0740556LPL ReceptorLysophospholipid ReceptorLPA1human lysophosphatidic acid receptor 1Inhibitorinhibitorinhibit

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製品名:
ONO-0740556
製品番号:
HY-150204
数量:
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