Cell-adhesion Peptides

Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM.

Fibronectin active fragment control is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins. Fibronectin active fragment control can be used as a control for Gly-Arg-Gly-Asp-Ser (HY-P0295).

Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury.

GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide.

Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain.

Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.

C-telopeptide is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD). C-telopeptide can be used in studies related to postmenopausal osteoporosis.