Propargyl-PEG3-alcohol
Based on 1 Customer Validation
Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 99.40%
- CAS No.: 208827-90-1
- Formula: C9H16O4
- Molecular Weight:188.22
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-130541
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Biotin-PEG3-azidePROTAC Linker -
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Propargyl-PEG3-acidADC/PROTAC Linker -
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N3-PEG4-C2-NH2PROTAC Linkers -
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BMPSADC Linker -
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Propargyl-PEG1-NH2PROTAC Linker -
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Propargyl-PEG4-alcoholPROTAC Linker -
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Amino-PEG3-C2-Azido -
HY-140128
DBCO-S-S-PEG3-biotinPROTAC Linker
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 208827-90-1
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Appearance Liquid (Density: 1.060±0.06 g/cm3)
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Molecular Weight 188.22
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Formula C9H16O4
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Color Colorless to light yellow
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SMILES
C#CCOCCOCCOCCO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Propargyl-PEG3-alcohol Related Classifications
HY-41921 Related Classifications
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