Propargyl-PEG3-amine
Based on 1 Customer Validation
Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 932741-19-0
- Formula: C9H17NO3
- Molecular Weight:187.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-W051634
Propargyl-PEG2-amineADC Linker -
HY-126976
Propargyl-PEG5-amineADC/PROTAC Linker -
HY-114670
Propargyl-PEG4-aminePROTAC Linker -
HY-W021042
Tris(3-hydroxypropyltriazolylmethyl)amineCuAAC Ligand -
HY-130182
Propargyl-PEG8-NH2ADC/PROTAC Linker -
HY-130180
Propargyl-PEG6-NH2PROTAC Linker -
HY-130373
Propargyl-PEG9-aminePROTAC Linker -
HY-126516
Propargyl-PEG4-NHS esterADC Linker -
HY-130388
Propargyl-PEG5-NHS esterADC/PROTAC Linker -
HY-116069
Propargyl-PEG1-NH2PROTAC Linker -
HY-133230
Propargyl-PEG10-aminePROTAC Linker -
HY-140034
Propargyl-PEG12-aminePROTAC Linkers
All PROTAC Linkers Isoforms
More
Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 932741-19-0
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Appearance Liquid (Density: 1.019±0.06 g/cm3)
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Molecular Weight 187.24
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Formula C9H17NO3
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Color Colorless to light yellow
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SMILES
C#CCOCCOCCOCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Propargyl-PEG3-amine Related Classifications
HY-140033 Related Classifications
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