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Cat. No.: HY-170335

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PROTAC c-Met degrader-2

PROTAC c-Met degrader-2 (PROTAC2) is a PROTAC-based c-Met degrader, with a DC₅₀ of 50 nM.
(Pink: c-Met ligand (HY-10338); Blue: Cereblon ligand (HY-136162A); Black: linker (HY-W442078)).

For research use only. We do not sell to patients.

CAS No.: 2254608-80-3
Formula: C₅₁H₅₀F₂N₆O₁₃
Molecular Weight:992.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

PROTAC c-Met degrader-2 Chemical Structure

CAS No.: 2254608-80-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC c-Met degrader-2 (PROTAC2) is a PROTAC-based c-Met degrader, with a DC₅₀ of 50 nM^[1]^[2]. (Pink: c-Met ligand (HY-10338); Blue: Cereblon ligand (HY-136162A); Black: linker (HY-W442078)).

All PROTACs Isoforms :

Parmacokinetics

Species	Dose	Route	CL	T_1/2	C₀	AUC_last	AUC_{INF_obs}	MRT_{INF_obs}	V_{ss_obs}	T_max	C_max	F
Mice^[1]	1 mg/kg	i.v.	43.2 mL/min/kg	0.90 h	2251 ng/mL	385 ng·h/mL	387 ng·h/mL	0.382 h	1.08 L/kg	/	/	/
Mice^[1]	10 mg/kg	i.p.	/	1.59 h	/	4555 ng·h/mL	4726 ng·h/mL	2.59 h	/	2 h	1066 ng/mL	122 %

Chemical Information

CAS No. 2254608-80-3
Molecular Weight 992.97
Formula C₅₁H₅₀F₂N₆O₁₃
SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCNC(CCOCCCOCCCOC4=CC5=NC=CC(OC6=CC=C(NC(C7(CC7)C(NC8=CC=C(C=C8)F)=O)=O)C=C6F)=C5C=C4OC)=O)=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nan Bai, et al. Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta. J Chem Inf Model [Content Brief]

[2]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2018226542A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PROTAC c-Met degrader-2

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC c-Met degrader-2 Related Classifications

HY-170335 Related Classifications