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Cat. No.: HY-174233

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PROTAC SARS-CoV-2 Mpro degrader-4

PROTAC SARS-CoV-2 Mpro degrader-4 (Compound LLP019) is a SARS-CoV-2 M^Pro PROTAC degrader with a DC₅₀ value of 4.7 μM. PROTAC SARS-CoV-2 Mpro degrader-4 induces M^Pro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Mpro degrader-4 is promising for research of COVID-19 and related coronavirus infections.
(Pink: SARS-CoV ligand (HY-32717); Blue: Cereblon ligand (HY-42771); Black: linker (HY-42149)).

For research use only. We do not sell to patients.

Formula: C₄₀H₃₇ClFN₇O₁₀
Molecular Weight:830.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SARS-CoV-2 Mpro degrader-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC SARS-CoV-2 Mpro degrader-4 (Compound LLP019) is a SARS-CoV-2 M^Pro PROTAC degrader with a DC₅₀ value of 4.7 μM. PROTAC SARS-CoV-2 Mpro degrader-4 induces M^Pro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Mpro degrader-4 is promising for research of COVID-19 and related coronavirus infections^[1]. (Pink: SARS-CoV ligand (HY-32717); Blue: Cereblon ligand (HY-42771); Black: linker (HY-42149)).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 830.21
Formula C₄₀H₃₇ClFN₇O₁₀
SMILES

CCOC1=C(NC(CCOCCOCCNC(COC2=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C=C(C(NC5=CC(Cl)=C(F)C=C5)=C(C#N)C=N6)C6=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Veeck C, et al. Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PROTAC SARS-CoV-2 Mpro degrader-4

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SARS-CoV-2 Mpro degrader-4 Related Classifications

HY-174233 Related Classifications