Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

  • Bioorg Med Chem Lett. 1999 Sep 20;9(18):2731-6. doi: 10.1016/s0960-894x(99)00472-2.
J S Zhang  1 ,  J Ding ,  Q M Tang ,  M Li ,  M Zhao ,  L J Lu ,  L J Chen ,  S T Yuan
Affiliations
  • 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. [email protected]
PMID: 10509925 DOI: 10.1016/s0960-894x(99)00472-2
Abstract

A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung Cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.