Pyrrolidine PNA: a novel conformationally restricted PNA analogue

  • Org Lett. 2000 Dec 28;2(26):4161-3. doi: 10.1021/ol000300l.
A Püschl  1 ,  T Tedeschi ,  P E Nielsen
Affiliations
  • 1. Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3C, DK-2200, Copenhagen, Denmark. [email protected]
PMID: 11150189 DOI: 10.1021/ol000300l
Abstract

[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.

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