Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3

  • Org Lett. 2001 Jan 25;3(2):247-50. doi: 10.1021/ol006891x.
S B Singh  1 ,  D L Zink ,  A W Dombrowski ,  G Dezeny ,  G F Bills ,  J P Felix ,  R S Slaughter ,  M A Goetz
Affiliations
  • 1. Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. [email protected]
PMID: 11430046 DOI: 10.1021/ol006891x
Abstract

[figure: see text] Blockers of the voltage-gated Potassium Channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.

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