Biosynthesis of quinolactacin A, a TNF production inhibitor

  • J Antibiot (Tokyo). 2006 Jul;59(7):418-27. doi: 10.1038/ja.2006.59.
Tatsuya Sasaki  1 ,  Senji Takahashi ,  Kenichi Uchida ,  Shinji Funayama ,  Masatsune Kainosho ,  Akira Nakagawa
Affiliations
  • 1. Department of Biosciences, Teikyo University, 1-1 Toyosatodai, Utsunomiya, Tochigi 320-8551, Japan.
PMID: 17025018 DOI: 10.1038/ja.2006.59
Abstract

Quinolactacins, which inhibit tumor necrosis factor production, contain a Quinolone skeleton conjugated with a y-lactam. The biosynthesis of quinolactacin was investigated by feeding experiments using 13C single-labeled precursors (sodium [1-13C]acetate, DL-[1-13C]-isoleucine, L-[methyl-13C]methionine, and sodium [1-13C]-anthranilate) and D-[U-13C]glucose.

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