alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents

  • Eur J Med Chem. 2007 Mar;42(3):386-93. doi: 10.1016/j.ejmech.2006.08.016.
Preeti Sharma  1 ,  Sangeeta Singh ,  Tanveer I Siddiqui ,  Vishnu S Singh ,  Bijoy Kundu ,  Philip Prathipati ,  Anil K Saxena ,  Dinesh K Dikshit ,  Leena Rastogi ,  Chetna Dixit ,  M B Gupta ,  G K Patnaik ,  Madhu Dikshit
Affiliations
  • 1. Medicinal Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India.
PMID: 17045703 DOI: 10.1016/j.ejmech.2006.08.016
Abstract

In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of alpha-amino acids were screened for their in vitro H(+)/K(+) ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its Proton Pump inhibition.

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