Inflammation and metabolic disorders

  • Nature. 2006 Dec 14;444(7121):860-7. doi: 10.1038/nature05485.
Gökhan S Hotamisligil  1
Affiliations
  • 1. Department of Genetics & Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA. [email protected]
PMID: 17167474 DOI: 10.1038/nature05485
Abstract

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the Other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and Cardiovascular Disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.