1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity

  • Bioorg Med Chem Lett. 2008 Jan 15;18(2):596-9. doi: 10.1016/j.bmcl.2007.11.080.
Gavin A Whitlock  1 ,  Julian Blagg ,  Paul V Fish
Affiliations
  • 1. Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. [email protected]
PMID: 18240382 DOI: 10.1016/j.bmcl.2007.11.080
Abstract

A novel series of 1-(2-phenoxyphenyl)methanamines is disclosed, which possess selective dual 5-HT and NA reuptake pharmacology. Analogues with good human in vitro metabolic stability, hERG selectivity and passive membrane permeability were identified.

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