5-HT/NA Reuptake inhibitor-1
5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability.
For research use only. We do not sell to patients.
- CAS No.: 844882-78-6
- Formula: C15H17NO
- Molecular Weight:227.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 660 nM (5-HT reuptake), 70 nM (NA reuptake)[1]
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
660 nM
Compound: 9
|
Inhibition of [3H]5HT uptake at human 5HT transporter expressed in HEK293 cells
Inhibition of [3H]5HT uptake at human 5HT transporter expressed in HEK293 cells
|
[PMID: 18240382] |
| HEK293 | IC50 |
70 nM
Compound: 9
|
Inhibition of [3H]NA uptake at human NA transporter expressed in HEK293 cells
Inhibition of [3H]NA uptake at human NA transporter expressed in HEK293 cells
|
[PMID: 18240382] |
Chemical Information
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CAS No. 844882-78-6
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Molecular Weight 227.30
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Formula C15H17NO
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SMILES
CN(C)CC1=C(C=CC=C1)OC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)