Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

  • J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):705-10. doi: 10.1080/10286020802016297.
Shu-Hong Guan  1 ,  Jia-Meng Xia ,  Min Yang ,  Xiao-Ming Wang ,  Xuan Liu ,  De-An Guo
Affiliations
  • 1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, China.
PMID: 18696320 DOI: 10.1080/10286020802016297
Abstract

Two new lanostanoid Triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human Cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.

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