Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic

  • J Antibiot (Tokyo). 1991 Apr;44(4):375-81. doi: 10.7164/antibiotics.44.375.
M Uramoto  1 ,  C J Kim ,  K Shin-Ya ,  H Kusakabe ,  K Isono ,  D R Phillips ,  J A McCloskey
Affiliations
  • 1. Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
PMID: 2032945 DOI: 10.7164/antibiotics.44.375
Abstract

A new nucleotide Antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The Antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 micrograms/ml.

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