A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid

  • Eur J Med Chem. 2011 Apr;46(4):1356-66. doi: 10.1016/j.ejmech.2011.01.061.
Rajbir Kaur  1 ,  Sheema Khan ,  Renu Chib ,  Tandeep Kaur ,  Parduman Raj Sharma ,  Jaswant Singh ,  Bhahwal Ali Shah ,  Subhash Chandra Taneja
Affiliations
  • 1. Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu Tawi 180001, India.
PMID: 21334793 DOI: 10.1016/j.ejmech.2011.01.061
Abstract

Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the Triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the Apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).