Triterpenoids with neurotrophic activity from Ganoderma lucidum

  • Nat Prod Res. 2011 Oct;25(17):1607-13. doi: 10.1080/14786419.2010.496367.
Xiao-Qi Zhang  1 ,  Fanny C F Ip ,  Dong-Mei Zhang ,  Li-Xin Chen ,  Wei Zhang ,  Yao-Lan Li ,  Nancy Y Ip ,  Wen-Cai Ye
Affiliations
  • 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
PMID: 21671206 DOI: 10.1080/14786419.2010.496367
Abstract

A new triterpenoid, 4,4,14α-trimethyl-5α-chol-7,9(11)-dien-3-oxo-24-oic acid (1), together with seven known triterpenoids, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by extensive spectroscopic analyses. Bioassay results revealed that compounds 1 and methyl ganoderic acid B (5) had nerve growth factor-like neuronal survival-promoting effects, whereas compounds 1, and 4-7 showed brain-derived neurotrophic factor-like neuronal survival-promoting activities.

Products