Methyl Ganoderic acid B
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects.
For research use only. We do not sell to patients.
- CAS No.: 81907-65-5
- Formula: C31H46O7
- Molecular Weight:530.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
7.25 μM
Compound: 51
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Cytotoxicity against human Bel7402 cells
Cytotoxicity against human Bel7402 cells
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[PMID: 23092389] |
| HeLa | IC50 |
101 μM
Compound: 51
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 23092389] |
| P388 | IC50 |
7.25 μM
Compound: 51
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 23092389] |
| SGC-7901 | IC50 |
7.25 μM
Compound: 51
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Cytotoxicity against human SGC7901 cells
Cytotoxicity against human SGC7901 cells
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[PMID: 23092389] |
In Vitro
Methyl Ganoderic acid B shows protective effects on fibroblasts expressing TrkA or TrkB receptors, with ED50 values of 0.69 ± 0.22 and 0.68 ± 0.21 μg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 81907-65-5
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Molecular Weight 530.69
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Formula C31H46O7
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SMILES
C[C@]12C3=C(C(C[C@@]1([C@@](CC2=O)([H])[C@H](C)CC(C[C@@H](C)C(OC)=O)=O)C)=O)[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])C[C@@H]3O)C
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Structure Classification
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Initial Source
Ganoderma lucidum (Curtis) P. Karst.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Serum-Free B27/Neurobasal Neuronal Maintenance Culture
Serum-free B27/Neurobasal culture is a defined neuronal maintenance method designed to support dissociated primary neurons while limiting serum-driven glial expansion; the readout is sustained neuronal survival, neurite extension, neuronal marker expression, synapse formation, and, when measured, electrophysiological or calcium activity. B27/Neurobasal was optimized in embryonic rat hippocampal neurons, where B27 supported >60% survival after 4 days above 160 plated cells/mm2 and Neurobasal reduced glial growth to <0. 5% by immunocytochemistry; later studies extended the approach to cortex, striatum, substantia nigra, septum, cerebellum, and dentate gyrus neurons.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methyl Ganoderic acid B Related Classifications
HY-N11640 Related Classifications
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