A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission

  • Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3350-3. doi: 10.1002/anie.201105653.
Nicholas R Conley  1 ,  Anca Dragulescu-Andrasi ,  Jianghong Rao ,  W E Moerner
Affiliations
  • 1. Department of Chemistry, Stanford University, CA 94305-5080, USA.
PMID: 22344705 DOI: 10.1002/anie.201105653
Abstract

A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.

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