Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities

  • Planta Med. 2014 Feb;80(2-3):201-8. doi: 10.1055/s-0033-1360173.
Cui-Ting Luo  1 ,  Huan-huan Zheng  1 ,  Shuang-Shuang Mao  1 ,  Mao-xun Yang  1 ,  Cheng Luo  2 ,  Heru Chen  1
Affiliations
  • 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
  • 2. State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
PMID: 24356906 DOI: 10.1055/s-0033-1360173
Abstract

Two new Xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known Xanthones (3-28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated Xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC50 value of 5.33 ± 0.09 µM, while the O-glycosylated Xanthones were poor α-glycosidase inhibitors.

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