Structure of a novel human granulocyte peptide with anti-ACTH activity

  • Biochem Biophys Res Commun. 1988 Aug 30;155(1):524-9. doi: 10.1016/s0006-291x(88)81118-5.
A Singh  1 ,  A Bateman ,  Q Z Zhu ,  S Shimasaki ,  F Esch ,  S Solomon
Affiliations
  • 1. Royal Victoria Hospital, Department of Medicine, Montreal, Quebec, Canada.
PMID: 2843187 DOI: 10.1016/s0006-291x(88)81118-5
Abstract

We report the purification, structure and biological properties of a peptide of novel sequence from human granulocytes that inhibits ACTH stimulated synthesis of corticosterone in rat adrenal cell suspensions. The peptide HP-4 is homologous to a previously described human granulocyte peptide HP-1 that has no anti-ACTH activity.

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