Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum

  • Fitoterapia. 2019 Jun;135:1-4. doi: 10.1016/j.fitote.2019.03.021.
Tianpeng Yin  1 ,  Yan Shu  2 ,  Hao Zhou  2 ,  Le Cai  3 ,  Zhongtao Ding  4
Affiliations
  • 1. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China.
  • 2. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • 3. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
  • 4. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
PMID: 30914332 DOI: 10.1016/j.fitote.2019.03.021
Abstract

Two novel 8,15-seco C19-diterpenoid Alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C19-diterpenoid Alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 72.63 ± 0.39 μM and 52.98 ± 0.50 μM, respectively.

Keywords
Aconitum nagarum Stapf; Diterpenoid alkaloids; Interleukin-6; Ranunculaceae.
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