Egg oil from Portunus trituberculatus alleviated obesity and regulated gut microbiota in mice

  • Sci Rep. 2020 May 21;10(1):8454. doi: 10.1038/s41598-020-65199-3.
Shiwei Hu  1 ,  Huicheng Yang  2 ,  Xiang Gao  3 ,  Shijie Li  4 ,  Wei Jiang  4 ,  Yu Liu  4
Affiliations
  • 1. Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhoushan, 316022, China. [email protected].
  • 2. Zhejiang Marine Development Research Institute, Zhoushan, 316021, China. [email protected].
  • 3. College of Food Science, Qingdao University, Qingdao, 266071, China.
  • 4. Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhoushan, 316022, China.
PMID: 32439940 DOI: 10.1038/s41598-020-65199-3
Abstract

Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome Insulin resistance resulting from abundant bioactive lipids. However, its effects on obesity and gut microbiota were unclear. Here, we evaluated whether Pt-egg oil could improve obesity and gut microbiota or not in high-fat diet feeding mice. Results exhibited that Pt-egg oil markedly reduced body weight and adipose weight gain, improved lipid accumulation and circulatory cytokines, inhibited epididymal adipose cell size. Moreover, Pt-egg oil modified gut microbiota, involving decreases in the ratio of Firmicutes to Bacteroidetes, Proteobacteria, Actinobacteria, and increase in Verrucomicrobia phylum. Pt-egg oil reduced serum and fecal lipopolysaccharide (LPS) levels and down-regulated Toll-like Receptor 4 pathway in both epididymal adipose and liver tissues. Meanwhile, Pt-egg oil increased short chain fatty acids and up-regulated of G-protein-coupled receptors in both epididymal adipose and liver tissues. These suggest that Pt-egg oil could be alternative food supplement for the prophylactic effects on anti-obesity and improvement in human gut health.

Products