Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

  • Phytochemistry. 2021 Apr:184:112678. doi: 10.1016/j.phytochem.2021.112678.
Yan-Zhe Jia  1 ,  Yu-Pei Yang  2 ,  Shao-Wu Cheng  3 ,  Liang Cao  4 ,  Qing-Ling Xie  5 ,  Meng-Yun Wang  6 ,  Bin Li  7 ,  Yu-Qing Jian  8 ,  Bin Liu  9 ,  Cai-Yun Peng  10 ,  Wei Wang  11
Affiliations
  • 1. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 2. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 3. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Key Laboratory of Colleges and Universities in Hunan Province for Cytobiology and Molecular Biotechnology, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China. Electronic address: [email protected].
  • 4. Institute of Agriculture Environment and Agroecology, Hunan Academy of Agriculture Sciences, Changsha, 410125, PR China. Electronic address: [email protected].
  • 5. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 6. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 7. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 8. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 9. College of Biology, Hunan University, Changsha, Hunan, 410082, PR China. Electronic address: [email protected].
  • 10. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
  • 11. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China. Electronic address: [email protected].
PMID: 33550198 DOI: 10.1016/j.phytochem.2021.112678
Abstract

Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2,2'-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene Lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu S, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A-S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity against APAP-induced toxicity in HepG-2 cells, four 2,2'-cyclolignans, heilaohuguosus A and L, tiegusanin I and kadsuphilol I showed good hepatoprotective activities against APAP toxicity in HepG-2 cells with cell survival rates of 53.5 ± 1.7%, 55.2 ± 1.2%, 52.5 ± 2.4%, and 54.0 ± 2.2% (positive control bicyclol, 52.1 ± 1.3%) at 10 μM, respectively.

Keywords
Fruit; Heilaohu; Hepatoprotective activity; Kadsura coccinea (Lem.) A. C. Sm.; Lignans; Phytochemical; Schisandraceae.
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