The biology of TREM receptors

  • Nat Rev Immunol. 2023 Sep;23(9):580-594. doi: 10.1038/s41577-023-00837-1.
Marco Colonna  1
Affiliations
  • 1. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. [email protected].
PMID: 36750615 DOI: 10.1038/s41577-023-00837-1
Abstract

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and Cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.