Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines

  • J Org Chem. 2024 Jul 5;89(13):9243-9254. doi: 10.1021/acs.joc.4c00171.
Vikram Phulwale  1 ,  Harshita Shet  1 ,  Krishna Chaitanya Gunturu  2 ,  Smruti Rekha Rout  3 ,  Rambabu Dandela  3 ,  Suyog Adhav  4 ,  Anant R Kapdi  1
Affiliations
  • 1. Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai 400019, India.
  • 2. School of Chemical Sciences, SRTM University, Nanded 431606, India.
  • 3. Department of Industrial and Engineering Chemistry, Institute of Chemical Technology-Indian Oil Odisha Campus , Samantpuri, Bhubaneswar, Odisha 751013, India.
  • 4. BASF Chemicals India Pvt. Ltd., Plot No 12, Thane Belapur Road, Navi Mumbai 400705, India.
PMID: 38878304 DOI: 10.1021/acs.joc.4c00171
Abstract

Chemoselective amination is a highly desired synthetic methodology, given its importance as a possible strategy to synthesize various drug molecules and agrochemicals. We, herein, disclose a highly chemoselective Cu(II)-PTABS-promoted amination of pyrimidine structural feature containing different halogen atoms.

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