Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

  • Signal Transduct Target Ther. 2025 Apr 23;10(1):130. doi: 10.1038/s41392-025-02214-x.
Jia He  #  1 ,  Haibo Yu  #  2 ,  Kunling Song  #  1 ,  Ailong Huang  3 ,  Yongjun Dang  4 ,  Juan Chen  5  6 ,  Zufeng Guo  7
Affiliations
  • 1. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy & Department of Breast and Thyroid Surgery of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • 2. Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • 3. Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. [email protected].
  • 4. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy & Department of Breast and Thyroid Surgery of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. [email protected].
  • 5. Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. [email protected].
  • 6. College of Biomedical Engineering, Chongqing Medical University, Chongqing, China. [email protected].
  • 7. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy & Department of Breast and Thyroid Surgery of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. [email protected].
  • # Contributed equally.
PMID: 40263266 DOI: 10.1038/s41392-025-02214-x
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