Design and Synthesis of Novel USP1 Inhibitors for Therapeutic Applications

  • ACS Med Chem Lett. 2025 Oct 30;16(11):2197-2199. doi: 10.1021/acsmedchemlett.5c00627.
Danielle E Hoyle  1 ,  Steven H Liang  1
Affiliations
  • 1. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
PMID: 41256996 DOI: 10.1021/acsmedchemlett.5c00627
Abstract

The present invention details novel inhibitors of Ubiquitin-Specific Protease 1 (USP1) and their pharmaceutically acceptable forms, compositions, and methods of use. These compounds demonstrate therapeutic potential for the treatment and prevention of USP1-related diseases, either as single agents or in combination with additional therapeutic agents.

Products