Unraveling RELA as a potential dioctyl terephthalate-related target regulates M2-like macrophages to induce an immunosuppressive microenvironment in colorectal cancer: a multi-omics data study by experimental validation

  • Mol Divers. 2026 Aug;30(4):6403-6419. doi: 10.1007/s11030-026-11545-y.
Yingdong Hou  1  2  3  4 ,  Zhijie Wang  5  6  7  8 ,  Hubin Xia  9 ,  Yifeng Zhou  5  6  7  8 ,  Xiaofeng Zhang  10  11  12  13
Affiliations
  • 1. Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 2. Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 3. Hangzhou Institute of Digestive Diseases, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 4. Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 5. Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310000, Zhejiang Province, China.
  • 6. Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.
  • 7. Hangzhou Institute of Digestive Diseases, Hangzhou, 310000, Zhejiang Province, China.
  • 8. Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.
  • 9. The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, 310000, Zhejiang Province, China.
  • 10. Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 11. Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 12. Hangzhou Institute of Digestive Diseases, Hangzhou, 310000, Zhejiang Province, China. [email protected].
  • 13. Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. [email protected].
PMID: 41966666 DOI: 10.1007/s11030-026-11545-y
Keywords
Colorectal cancer; Dioctyl terephthalate; Immunosuppressive microenvironment; Molecular dynamics simulation; RELA.
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