Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5

  • J Antibiot (Tokyo). 1993 Jan;46(1):56-64. doi: 10.7164/antibiotics.46.56.
A Yoshimoto  1 ,  S Fujii ,  O Johdo ,  K Kubo ,  H Nishida ,  R Okamoto ,  T Takeuchi
Affiliations
  • 1. Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
PMID: 8436560 DOI: 10.7164/antibiotics.46.56
Abstract

A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxyl-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.

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