Homobotcinolide: a biologically active natural homolog of botcinolide from Botrytis cinerea

  • Biosci Biotechnol Biochem. 1996 Apr;60(4):656-8. doi: 10.1271/bbb.60.656.
H G Cutler  1 ,  S R Parker ,  S A Ross ,  F G Crumley ,  P R Schreiner
Affiliations
  • 1. USDA, ARS, Richard B. Russell Research Center, Athens, Georgia 30613, USA.
PMID: 8829534 DOI: 10.1271/bbb.60.656
Abstract

A novel natural product exhibiting biological activity was isolated from a strain of Botrytis cinerea that had infected raspberry fruit (Rubus ideaus). Liquid fermentation and bioassay-directed fractionation of the organism yielded a compound with molecular formula C22H38O8 that is trivially named homobotcinolide. It significantly inhibited etiolated wheat coleoptile growth. Greenhouse-grown bean, corn, and tobacco Plants were also affected by exogenous application of homobotcinolide, severe chlorosis and necrosis being exhibited in corn. The compound is a polyhydroxylated nonalactone esterified with 4-hydroxy-2-decenoic acid.

Products