Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy
- Cancer Lett. 1996 Dec 20;110(1-2):63-70. doi: 10.1016/s0304-3835(96)04461-8.
Affiliations
- 1. Department of Biological Chemistry, University Medical Center, Franfurt am Main, Germany.
PMID: 9018082
DOI: 10.1016/s0304-3835(96)04461-8
Abstract
The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced Apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of Apoptosis in malignant cells.