SAR of novel biarylmethylamine dopamine D4 receptor ligands

  • Bioorg Med Chem Lett. 1998 Aug 4;8(15):2033-8. doi: 10.1016/s0960-894x(98)00361-8.
M Arlt  1 ,  H Böttcher ,  A Riethmüller ,  G Schneider ,  G D Bartoszyk ,  H Greiner ,  C A Seyfried
Affiliations
PMID: 9873481 DOI: 10.1016/s0960-894x(98)00361-8
Abstract

SAR for a novel series of dopamine D4 receptor ligands is shown. Very selective, highly potent compounds like 1-(2-pyrimidinyl)-4-(3-(3-thienyl)-benzyl)-piperazine (5f) and 2-(4-(1-fluorenylmethyl)-1-piperazinyl)-pyrimidine (8c) were obtained.