R-BC154 acetate
R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.
For research use only. We do not sell to patients.
- Formula: C57H65N9O15S3
- Molecular Weight:1212.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
α9β1 |
In Vitro
R-BC154 acetate has 3 times greater affinities for α9β1 (Ki=12.7 nM) relative to α4β1 (Ki=38.0 nM) under Ca2+/Mg2+ conditions in human glioblastoma LN18 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice (6-8 weeks old)[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection
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Result:Was capable of binding haemopoietic progenitor cells and HSC within mice bone marrow in vivo.
Chemical Information
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Molecular Weight 1212.37
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Formula C57H65N9O15S3
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SMILES
CC(O)=O.CC/[N+](CC)=C1C=C2OC3=C(C=CC(N(CC)CC)=C3)C(C4=CC=C(S(NCC5=CN([C@H]6CN(S(=O)(C7=CC=CC=C7)=O)[C@H](C(N[C@H](C(O)=O)CC8=CC=C(OC(N9CCCC9)=O)C=C8)=O)C6)N=N5)(=O)=O)C=C4S(=O)([O-])=O)=C2C=C\1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R-BC154 acetate Related Classifications
HY-136214 Related Classifications
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