Reactive oxygen responsive hydrogel

Reactive oxygen species responsive hydrogels are a novel class of smart hydrogels, formed by the cross-linking of ROS-responsive modules through covalent, coordination, or supramolecular interactions. Due to the introduction of these ROS-responsive modules, these hydrogels exhibit a sensitive response to the oxidative stress microenvironment present in organisms. PVA-TSPBA hydrogel is a hydrogel formed by the cross-linking polymerization of polyvinyl alcohol (PVA) and the reactive oxygen species-sensitive cross-linking agent N1-(4-benzyl borate)-N3-(4-phenyl borate)N1,N1,N3,N3-tetramethyl-1,3-propanediamine (TSPBA). This hydrogel consists of two parts: a boric acid precursor (TSPBA) and an aqueous solution of PVA. The boric acid bonds on TSPBA and the hydroxyl groups on PVA rapidly cross-link to form borate ester bonds, thus forming the hydrogel.