CHRM1 Protein, Rat (His)
CHRM1, the muscarinic acetylcholine receptor, mediates cellular responses, including adenylate cyclase inhibition, phosphoinositide breakdown, and potassium channel modulation through G protein actions.It engages with GPRASP2 and TMEM147, contributing to a complex network of signaling pathways and cellular processes regulated by the receptor.CHRM1 Protein, Rat (His) is the recombinant rat-derived CHRM1 protein, expressed by E.coli , with N-6*His labeled tag.
- Species: Rat
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
CHRM1, the muscarinic acetylcholine receptor, mediates cellular responses, including adenylate cyclase inhibition, phosphoinositide breakdown, and potassium channel modulation through G protein actions.It engages with GPRASP2 and TMEM147, contributing to a complex network of signaling pathways and cellular processes regulated by the receptor.CHRM1 Protein, Rat (His) is the recombinant rat-derived CHRM1 protein, expressed by E.coli , with N-6*His labeled tag.
The muscarinic acetylcholine receptor, represented by CHRM1, is responsible for mediating diverse cellular responses, such as the inhibition of adenylate cyclase, phosphoinositide breakdown, and modulation of potassium channels through G protein-mediated actions. Its primary transducing effect involves Pi turnover. Additionally, CHRM1 interacts with GPRASP2 and TMEM147, contributing to the intricate network of signaling pathways and cellular processes regulated by this receptor.
Technical Parameters
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Species Rat
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Source E. coli
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Tag N-6*His
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Accession
P08482 (R210-T366)
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Molecular Construction
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N-term
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6*His
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CHRM1 (R210-T366)
Accession # P08482 -
C-term
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Protein Length
Cytoplasmic Domain
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Synonyms
CHRM1; Muscarinic Acetylcholine Receptor; Cholinergic Receptor Muscarinic 1; HM1; Acetylcholine Receptor, Muscarinic 1; M1R; Muscarinic Acetylcholine Receptor M1; M1
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AA Sequence
RIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAART
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Predicted Molecular Mass
21.1 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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