Chrm1 - cholinergic receptor, muscarinic 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25229

Summary

Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; neuromuscular synaptic transmission; and positive regulation of intracellular protein transport. Located in several cellular components, including axon terminus; dendrite; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]

Chrm1 Products (1)

mRNA Protein Name
NM_080773.2 NP_542951.1 muscarinic acetylcholine receptor M1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled acetylcholine receptor activity IDA
IDA: Inferred from direct assay
12534975 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
12534975 RGD
involved in neuromuscular synaptic transmission IDA
IDA: Inferred from direct assay
12534975 RGD
involved in positive regulation of intracellular protein transport IDA
IDA: Inferred from direct assay
17908240 RGD
Cellular Component GO Annotation Evidence References Source
located in asymmetric synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8182478 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8182478 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8182478 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
8182478 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8182478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M1

  • Cholinergic receptor, muscarin 1

  • m1 muscarinic acetylcholine receptor protein

Recombinant Chrm1 Proteins

Cat. No. Product Name Accession Purity
HY-P72138 CHRM1 Protein, Rat (His) P08482 (R210-T366) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0298 Clemastine 99.26% Yes

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0735 Phellodendrine chloride 99.68% Unkown
HY-N0427 Phellodendrine 99.60% Unkown
HY-RS02660 CHRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18169 Chrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24643 Chrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm1 NCBI NCBI:1128