gucD Protein, Bacillus subtilis
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis is the recombinant gucD protein, expressed by E. coli , with tag free.
- Species: Others
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis is the recombinant gucD protein, expressed by E. coli , with tag free.
KYAT1 protein orchestrates the irreversible transamination of the L-tryptophan metabolite L-kynurenine, culminating in the formation of kynurenic acid (KA). This process holds significance within the tryptophan catabolic pathway and yields KA, known for its broad-spectrum antagonistic activity against the three ionotropic excitatory amino acid receptors, among others. Beyond its role in tryptophan metabolism, KYAT1 is involved in the transformation of cysteine conjugates from specific halogenated alkenes and alkanes into reactive metabolites. Furthermore, KYAT1 catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, leading to the cleavage of the C-S or C-Se bond. The diverse enzymatic activities of KYAT1 underscore its involvement in key metabolic pathways and xenobiotic processing.
Technical Parameters
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Species Others
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Source E. coli
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Tag Tag Free
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Accession
P42236 (S2-P488)
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Gene ID938406
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Molecular Construction
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N-term
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gucD (S2-P488)
Accession # P42236 -
C-term
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Protein Length
Partial
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Synonyms
BSU02470; ycbD; gucD; 2,5-dioxovalerate dehydrogenase; alphaKGSA dehydrogenase; EC:1.2.1.26; Alpha-ketoglutaric semialdehyde dehydrogenase
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AA Sequence
SVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQNSTAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTLPEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPVAIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQGLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEAVITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASKNQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIFGPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAGVELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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