PRMT7 Protein, Human (sf9, Flag)
PRMT7 Protein, Human (sf9, Flag) is the recombinant human-derived PRMT7, expressed by Sf9 insect cells , with N-Flag labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
PRMT7 Protein, Human (sf9, Flag) is the recombinant human-derived PRMT7, expressed by Sf9 insect cells , with N-Flag labeled tag. ,
PRMT7 is an arginine methyltransferase capable of catalyzing the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for MMA production. It specifically mediates the symmetrical dimethylation of arginine residues in small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), a process essential for snRNP core particle assembly and biogenesis. PRMT7 also symmetrically dimethylates histone H4 at 'Arg-3' to generate H4R3me2s. In gene imprinting, PRMT7 is recruited by CTCFL to the H19 imprinted control region (ICR), where it methylates histone H4 to form H4R3me2s, potentially facilitating DNA methyltransferase recruitment. The enzyme may further contribute to embryonic stem cell (ESC) pluripotency. In vitro, PRMT7 can methylate histone H2A and myelin basic protein (MBP), though the physiological relevance remains unclear.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-Flag
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Accession
Q9NVM4-1 (K2-D692)
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Gene ID54496
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Molecular Construction
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N-term
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Flag
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PRMT7 (K2-D692)
Accession # Q9NVM4-1 -
C-term
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Protein Length
Partial
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Synonyms
PRMT7; KIAA1933; Protein Arginine Methyltransferase 7; FLJ10640; [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7; Type III Protein Arginine Methyltransferase; Histone-Arginine N-Methyltransferase PRMT7; Protein Arginine N-Methyltransferase; Prot
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AA Sequence
KIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
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Predicted Molecular Mass
80 kDa
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Molecular Weight
Approximately 75-80 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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