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Cat. No.: HY-133161

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RhlR agonist-1

RhlR agonist-1 is a N-acylated L-homoserine lactone and is a selective quorum sensing receptor RhlR agonist. RhlR agonist-1 can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1061591-41-0
Formula: C₁₀H₁₅NO₃
Molecular Weight:197.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RhlR agonist-1 Chemical Structure

CAS No.: 1061591-41-0

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

RhlR agonist-1 is a N-acylated L-homoserine lactone and is a selective quorum sensing receptor RhlR agonist. RhlR agonist-1 can be used for the research of bacterial infections^[1].

In Vitro

RhlR agonist-1 (Compound S4) (100 nM-1 mM) potently activates RhlR in recombinant E. coli JLD271 with an EC₅₀ of 2.8 μM, inducing 91% of the maximum RhlR activity seen with the native ligand BHL at 100 μM^[1].
RhlR agonist-1 potently activates RhlR in P. aeruginosa PAO-JP2 with an EC₅₀ of 4.5 μM, inducing 105% of the maximum RhlR activity seen with the native ligand BHL at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1061591-41-0
Molecular Weight 197.23
Formula C₁₀H₁₅NO₃
SMILES

N(C(=O)C1CCCC1)[C@@H]2C(=O)OCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eibergen NR, et al. Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa. Chembiochem. 2015;16(16):2348-2356. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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