S-EIT hydrobromide  (Synonyms: S-Ethylisothiourea hydrobromide)

S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

EIT (S-ethylisothiourea) Hydrobromide is a selective inhibitor of type II NOS. EIT elicited a dose-dependent and > 95% inhibition of the LPS-induced increase in plasma [NOx]. The ED50 values for EIT was 0.4 mg/kg. Pretreatment with L-arginine (but not D-arginine) prevented the mortality, while not affecting the type II NOS-dependent NO production, suggesting the toxicity may be due to inhibition of one of the other NOS isoforms (endothelial or neuronal)[1 ]. Selective NOS II antagonists attenuate but do not block shear stress-induced vasodilation in the fetal lung. Stimulation of NOS II activity, perhaps from smooth muscle cells, contributes in part to the NO-mediated fall in PVR (pulmonary vascular resistance) during shear stress-induced pulmonary vasodilation. Spleen cells stimulated with alloantigens in the presence of AMT or S-ethylisothiourea (EIT), an another selective iNOS inhibitor, produced considerably more interleukin (IL)-4 and IL-10 than the cells stimulated in the absence of iNOS inhibitors. The production of Th1 cytokines IL-2 and interferon (IFN)-gamma was not enhanced by the inhibition of NO synthesis. Acute administration of EIT (380 nmol/h), another inducible nitric Oxide synthase selective inhibitor, also attenuated pregnancy-induced increases in glomerular filtration rate and effective renal plasma flow.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

185.09

C₃H₉BrN₂S

1071-37-0

Solid

White to yellow

NC(SCC)=N.Br

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)