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  4. S-EIT hydrobromide

S-EIT hydrobromide  (Synonyms: S-Ethylisothiourea hydrobromide)

Cat. No.: HY-101252
COA
SDS
Handling Instructions Technical Support

S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

S-EIT hydrobromide

S-EIT hydrobromide Chemical Structure

CAS No. : 1071-37-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 g In-stock
50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

S-EIT hydrobromide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

EIT (S-ethylisothiourea) Hydrobromide is a selective inhibitor of type II NOS. EIT elicited a dose-dependent and > 95% inhibition of the LPS-induced increase in plasma [NOx]. The ED50 values for EIT was 0.4 mg/kg. Pretreatment with L-arginine (but not D-arginine) prevented the mortality, while not affecting the type II NOS-dependent NO production, suggesting the toxicity may be due to inhibition of one of the other NOS isoforms (endothelial or neuronal)[1 ]. Selective NOS II antagonists attenuate but do not block shear stress-induced vasodilation in the fetal lung. Stimulation of NOS II activity, perhaps from smooth muscle cells, contributes in part to the NO-mediated fall in PVR (pulmonary vascular resistance) during shear stress-induced pulmonary vasodilation. Spleen cells stimulated with alloantigens in the presence of AMT or S-ethylisothiourea (EIT), an another selective iNOS inhibitor, produced considerably more interleukin (IL)-4 and IL-10 than the cells stimulated in the absence of iNOS inhibitors. The production of Th1 cytokines IL-2 and interferon (IFN)-gamma was not enhanced by the inhibition of NO synthesis. Acute administration of EIT (380 nmol/h), another inducible nitric Oxide synthase selective inhibitor, also attenuated pregnancy-induced increases in glomerular filtration rate and effective renal plasma flow.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-EIT hydrobromide Related Antibodies
Molecular Weight

185.09

Formula

C3H9BrN2S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NC(SCC)=N.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (540.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4028 mL 27.0139 mL 54.0278 mL
5 mM 1.0806 mL 5.4028 mL 10.8056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (245 KB) HNMR (122 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4028 mL 27.0139 mL 54.0278 mL 135.0694 mL
5 mM 1.0806 mL 5.4028 mL 10.8056 mL 27.0139 mL
10 mM 0.5403 mL 2.7014 mL 5.4028 mL 13.5069 mL
15 mM 0.3602 mL 1.8009 mL 3.6019 mL 9.0046 mL
20 mM 0.2701 mL 1.3507 mL 2.7014 mL 6.7535 mL
25 mM 0.2161 mL 1.0806 mL 2.1611 mL 5.4028 mL
30 mM 0.1801 mL 0.9005 mL 1.8009 mL 4.5023 mL
40 mM 0.1351 mL 0.6753 mL 1.3507 mL 3.3767 mL
50 mM 0.1081 mL 0.5403 mL 1.0806 mL 2.7014 mL
60 mM 0.0900 mL 0.4502 mL 0.9005 mL 2.2512 mL
80 mM 0.0675 mL 0.3377 mL 0.6753 mL 1.6884 mL
100 mM 0.0540 mL 0.2701 mL 0.5403 mL 1.3507 mL
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S-EIT hydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-EIT1071-37-0S-EthylisothioureaBiochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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