1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Cannabinoid Receptor
    NO Synthase
  3. (S)-MRI-1867

(S)-MRI-1867 

Cat. No.: HY-141411A
Handling Instructions

(S)-MRI-1867 is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist. (S)-MRI-1867 ameliorates obesity-induced chronic kidney disease (CKD).

For research use only. We do not sell to patients.

(S)-MRI-1867 Chemical Structure

(S)-MRI-1867 Chemical Structure

CAS No. : 1998760-00-1

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Description

(S)-MRI-1867 is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist. (S)-MRI-1867 ameliorates obesity-induced chronic kidney disease (CKD)[1].

IC50 & Target[1]

CB1

 

iNOS

 

In Vitro

(S)-MRI-1867 can simultaneously inhibit CB1 receptors and iNOS in peripheral organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-MRI-1867 (3 mg/kg; p.o.; for 28 days) improves renal morphological and functional parameters in diet-induced obese mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male C57Bl/6J mice (diet-induced obesity)[1]
Dosage: 3 mg/kg
Administration: P.o.; for 28 days
Result: Improved kidney morphology and function in diet-induced obese mice.
Molecular Weight

547.98

Formula

C₂₅H₂₁ClF₃N₅O₂S

CAS No.
SMILES

O=S(/N=C(N1N=C(C2=CC=C(Cl)C=C2)[[email protected]@H](C3=CC=CC=C3)C1)/N=C(N)/C)(C4=CC=C(C(F)(F)F)C=C4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S)-MRI-1867Cannabinoid ReceptorNO SynthaseNitric oxide synthasesNOSperipherallyoralobesitychronickidneyCKDInhibitorinhibitorinhibit

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(S)-MRI-1867
Cat. No.:
HY-141411A
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