SDH-IN-48
SDH-IN-48 is a succinate dehydrogenase (SDH) inhibitor, with an IC50 of 0.056 μM against porcine SDH. SDH-IN-48 binds to the SDH active pocket through multiple non-covalent interactions. SDH-IN-48 can be used in related research on rice sheath blight disease.
For research use only. We do not sell to patients.
- Formula: C21H16F6N4O2
- Molecular Weight:470.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SDH 0.056 μM (IC50) |
In Vitro
SDH-IN-48 (compound 8r) potently inhibits porcine heart-derived succinate dehydrogenase with an IC50 of 0.056 μM and forms a stable, high-affinity complex with the enzyme via multiple favorable interactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 470.37
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Formula C21H16F6N4O2
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SMILES
O=C(C1=C(F)N(C)N=C1C(F)F)NC2=CC=CC(/C(C3=CC=CC(C(F)(F)F)=C3)=N\OC)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-48 Related Classifications
HY-187992 Related Classifications
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